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@corresponding author; #contributed equally
2022 de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA … Kooij TWA#@ & Dechering KJ#@. Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nat. Commun. 13, 2158. (“Malaria research towards disease elimination” collection) https://doi.org/10.1038/s41467-022-29688-5
2021 de Vries LE#, Lunghi M#, Krishnan A, Kooij TWA#@ & Soldati-Favre D#@. Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets. PLoS Pathog. 17, e1010124. https://doi.org/10.1371/journal.ppat.1010124
2021 van Esveld SL, Meerstein-Kessel L#, Boshoven C#, Baaij JF, Barylyuk K, Coolen JPM … Huynen MA@. A prioritized and validated resource of mitochondrial proteins in Plasmodium identifies unique biology. mSphere e0061421. https://doi.org/10.1128/mSphere.00614-21
2021 Verhoef JMJ, Meissner M & Kooij TWA@. Organelle dynamics in apicomplexan parasites. mBio 12, e01409–21. https://doi.org/10.1128/mBio.01409-21
2021 Boltryk SD, Passecker A, Alder A, Carrington E, van de Vegte-Bolmer M, van Gemert G-J … Voss TS@. CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research. Nat. Commun. 12, 4806. (“Malaria research towards disease elimination” collection) https://doi.org/10.1038/s41467-021-24954-4
2021 Van Strien J, Haupt A, Schulte U, Braun H-P, Cabrera-Orefice A, Choudhary JS … Huynen MA@. CEDAR, an online resource for the reporting and exploration of complexome profiling data. Biochim Biophys Acta Bioenerg 1862, 148411. https://doi.org/10.1016/j.bbabio.2021.148411
2021 Evers F, Cabrera-Orefice A, Elurbe DM, Kea-Te Lindert M, Boltryk SD, Voss TS, Huynen MA, Brandt U & Kooij TWA@. Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum. Nat. Commun. 12, 3820. (“Malaria research towards disease elimination” collection; RIMLS best publication 2021) https://doi.org/10.1038/s41467-021-23919-x
2020 Genzel L@, Adan R, Berns A, van den Beucken J, Blokland A, Boddeke EHWGM … Homberg JR@. How the COVID-19 pandemic highlights the necessity of animal research. Curr. Biol. 30, R1014–R1018. https://doi.org/10.1016/j.cub.2020.08.030
2020 Kenthirapalan S#, Tran PN#, Kooij TWA#, Ridgway MC, Rauch M, Brown SHJ, Mitchell TW, Matuschewski K@ & Maier AG@. Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation. Int. J. Parasitol. 50, 511–522. https://doi.org/10.1016/j.ijpara.2020.03.009
2020 Warncke JD, Passecker A, Kipfer E, Brand F, Pérez-Martínez L, Proellochs NI, Kooij TWA, Butter F, Voss TS & Beck H-P@. The PHIST protein GEXP02 targets the host cytoskeleton during sexual development of Plasmodium falciparum. Cell. Microbiol. 22, e13123. (Cover) https://doi.org/10.1111/cmi.13123
2019 Schalkwijk J#@, Allman EL#, Jansen PAM#, de Vries LE#, Verhoef JMJ, Jackowski S … Hermkens PHH# & Dechering KJ#@. Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Sci. Transl. Med. 11, eaas9917. https://doi.org/10.1126/scitranslmed.aas9917
2018 Matz JM@, Goosmann C, Matuschewski K & Kooij TWA@. An unusual prohibitin regulates malaria parasite mitochondrial membrane potential. Cell Rep. 23, 756–767. (Issue highlight) https://doi.org/10.1016/j.celrep.2018.03.088
2018 Meerstein-Kessel L, van der Lee R, Stone W, Lanke K, Baker DA, Alano P … Bousema T# & Huynen MA#@. Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites. Sci. Rep. 8, 410. https://doi.org/10.1038/s41598-017-18840-7
2016 Weiner 3rd J & Kooij TWA@. Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targets. Microbial Cell 3, 380–390. (Cover) https://doi.org/10.15698/mic2016.10.534
2016 Rijpma SR, van der Velden M, Annoura T, Matz JM, Kenthirapalan S, Kooij TWA … Koenderink JB@. Vital and dispensable roles of Plasmodium multidrug resistance transporters during blood- and mosquito-stage development. Mol. Microbiol. 101, 78–91. https://doi.org/10.1111/mmi.13373
2016 Kenthirapalan S, Waters AP, Matuschewski K & Kooij TWA@. Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite. Nat. Commun. 7, 10519. (Faculty of 1000, 2*) https://doi.org/10.1038/ncomms10519
2015 Matz JM, Goosmann C, Brinkmann V, Grützke J, Ingmundson A, Matuschewski K & Kooij TWA@. The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions. Sci. Rep. 5, 12532. https://doi.org/10.1038/srep12532
2015 Matz JM, Ingmundson A, Costa Nunes J, Stenzel W, Matuschewski K & Kooij TWA@. In vivo function of PTEX88 in malaria parasite sequestration and virulence. Eukaryot. Cell 14, 528–534. (Cover) https://doi.org/10.1128/EC.00276-14
2015 Lewis MD, Behrends J, Sá E Cunha C, Mendes AM, Lasitschka F, Sattler JM … Mueller A-K@. Chemical attenuation of Plasmodium in the liver modulates severe malaria disease progression. J. Immunol. 194, 4860–4870. https://doi.org/10.4049/jimmunol.1400863
2015 Matz JM & Kooij TWA@. Towards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium berghei. Pathog. Glob. Health 109, 46–60. (Invited, Cover, Editor’s Choice) https://doi.org/10.1179/2047773215Y.0000000006
2014 Andreadaki M, Morgan RN, Deligianni E, Kooij TWA, Santos JM, Spanos L, Matuschewski K, Louis C, Mair GR & Siden-Kiamos I. Genetic crosses and complementation reveal essential functions for the Plasmodium stage-specific actin2 in sporogonic development. Cell. Microbiol. 16, 751–767. https://doi.org/10.1111/cmi.12274
2014 Haussig JM, Burgold J, Hafalla JCR, Matuschewski K@ & Kooij TWA. Signatures of malaria vaccine efficacy in ageing murine immune memory. Parasite Immunol. 36, 199–206. https://doi.org/10.1111/pim.12104
2014 Haussig JM, Matuschewski K & Kooij TWA@. Identification of vital and dispensable sulfur utilization factors in the Plasmodium apicoplast. PLoS ONE 9, e89718. https://doi.org/10.1371/journal.pone.0089718
2014 Kenthirapalan S, Waters AP, Matuschewski K & Kooij TWA@. Copper-transporting ATPase is important for malaria parasite fertility. Mol. Microbiol. 91, 315–325. https://doi.org/10.1111/mmi.12461
2013 Matz JM, Matuschewski K & Kooij TWA@. Two putative protein export regulators promote Plasmodium blood stage development in vivo. Mol. Biochem. Parasitol. 191, 44–52. (Cover; Malaria Nexus Feature Article) https://doi.org/10.1016/j.molbiopara.2013.09.003
2013 Haussig JM, Matuschewski K & Kooij TWA@. Experimental genetics of Plasmodium berghei NFU in the apicoplast iron-sulfur cluster biogenesis pathway. PLoS ONE 8, e67269. https://doi.org/10.1371/journal.pone.0067269
2012 Kenthirapalan S, Waters AP, Matuschewski K & Kooij TWA@. Flow cytometry-assisted rapid isolation of recombinant Plasmodium berghei parasites exemplified by functional analysis of aquaglyceroporin. Int. J. Parasitol. 42, 1185–1192. (Cover; Malaria Nexus Feature Article) https://doi.org/10.1016/j.ijpara.2012.10.006
2012 Kooij TWA@, Rauch MM & Matuschewski K. Expansion of experimental genetics approaches for Plasmodium berghei with versatile transfection vectors. Mol. Biochem. Parasitol. 185, 19–26. (Malaria Nexus Feature Article) https://doi.org/10.1016/j.molbiopara.2012.06.001
2011 Deligianni E, Morgan RN, Bertuccini L, Kooij TWA, Laforge A, Nahar C … Siden-Kiamos I@. Critical role for a stage-specific actin in male exflagellation of the malaria parasite. Cell. Microbiol. 13, 1714–1730. https://doi.org/10.1111/j.1462-5822.2011.01652.x
2011 Haussig JM, Matuschewski K & Kooij TWA@. Inactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoites. Mol. Microbiol. 81, 1511–1525. (Cover) https://doi.org/10.1111/j.1365-2958.2011.07787.x
2009 Lamikanra AA, Theron M, Kooij TWA & Roberts DJ@. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors. PLoS ONE 4, e8446. https://doi.org/10.1371/journal.pone.0008446
2009 Spork S, Hiss JA, Mandel K, Sommer M, Kooij TWA, Chu T, Schneider G, Maier UG & Przyborski JM@. An unusual ERAD-like complex is targeted to the apicoplast of Plasmodium falciparum. Eukaryot. Cell 8, 1134–1145. https://doi.org/10.1128/EC.00083-09
2009 Rayment R, Kooij TWA, Zhang W, Siebold C, Murphy MF, Allen D, Willcox N@ & Roberts DJ@. Evidence for the specificity for platelet HPA-1a alloepitope and the presenting HLA-DR52a of diverse antigen-specific helper T cell clones from alloimmunized mothers. J. Immunol. 183, 677–686. https://doi.org/10.4049/jimmunol.0801473
2008 Carlton JM@, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E … Fraser-Liggett CM. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. 455, 757–763. (Faculty of 1000, 4*) https://doi.org/10.1038/nature07327
2008 van Ooij C, Tamez P, Bhattacharjee S, Hiller NL, Harrison T, Liolios K … Haldar K@. The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathog. 4, e1000084. https://doi.org/10.1371/journal.ppat.1000084
2007 Kooij TWA@ & Matuschewski K. Triggers and tricks of Plasmodium sexual development. Curr. Opin. Microbiol. 10, 547–553. (Invited) https://doi.org/10.1016/j.mib.2007.09.015
2007 Cheesman S@, Creasey A, Degnan K, Kooij T, Afonso A, Cravo P, Carter R & Hunt P. Validation of PyrosequencingTM for accurate and high throughput estimation of allele frequencies in malaria parasites. Mol. Biochem. Parasitol. 152, 213–219. https://doi.org/10.1016/j.molbiopara.2006.12.008
2006 Kooij TWA, Janse C & Waters AP@. Plasmodium post-genomics: better the bug you know? Nat. Rev. Microbiol. 4, 344–357. (Invited) https://doi.org/10.1038/nrmicro1392
2005 Kooij TWA, Carlton JM, Bidwell SL, Hall N, Ramesar J, Janse C & Waters AP@. A Plasmodium whole-genome synteny map: indels and synteny breakpoints as foci for species-specific genes. PLoS Pathog. 1, e44. https://doi.org/10.1371/journal.ppat.0010044
2005 Kooij TWA, Franke-Fayard BMD, Renz J, Kroeze H, van Dooren MW, Ramesar J, Augustijn KD, Janse C & Waters AP@. Plasmodium berghei α-tubulin II: a role in both male gamete formation and asexual blood stages. Mol. Biochem. Parasitol. 144, 16–26. https://doi.org/10.1016/j.molbiopara.2005.07.003
2005 Hall N#@, Karras M#, Raine JD#, Carlton JM, Kooij TWA, Berriman M … Waters AP@ & Sinden RE@. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science 307, 82–86. (Faculty of 1000, 1*) https://doi.org/10.1126/science.1103717
2002 Carlton JM@, Angiuoli SV, Suh BB, Kooij TWA, Pertea M, Silva JC … Carucci DJ. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. 419, 512–519. (Cover) https://doi.org/10.1038/nature01099
1999 Pap EH@, Drummen GP, Winter VJ, Kooij TWA, Rijken P, Wirtz KW, Op den Kamp JA, Hage WJ & Post JA. Ratio-fluorescence microscopy of lipid oxidation in living cells using C11-BODIPY581/591. FEBS Lett. 453, 278–282. https://doi.org/10.1016/S0014-5793(99)00696-1
Taco Kooij 